Breast Cancer :: essays research papers

Scientists lead fin totallyy found verboten why MPA medroxyprogesterone, some otherwise known as Provera performs just as well in low doses in small children who are relations with early sex traits, as it does for women in high doses with breast cancer. You whitethorn have heard of Provera before as the drug that delivers ductless gland replacement therapy for women who are going through menopause. Two scientists, named Lee and Auchus were toilsome to figure out why Provera is able to treat two early puberty as well as breast cancer. During the pre-teen eld a chemical is unleashd in the brain called gonadotropin-releasing hormone (GnRH). In a normal pre-teen body GnRH tells the ovaries and testes when to start making steroids. Low doses of Provera have shown to bind to the receptors in the brain and block GnRH end product. There are trusted disorders that children can develop- when their GnRH is not released into the brain. For instance, gonadotropin-independent precocity , this is when the Childs ovaries or testes still make steroids even without the release of GnRH. Since these children are still producing steroids without GnRH being released, low doses of Provera are not effective. For the body to produce steroid hormones it must convert cholesterol into estrogens and other related substances. In order for this process to take place, several step are involved which are controlled by a certain enzyme. In knowing this, Lee wanted to find out if blocking the operation of an enzyme would be reached with high doses of Provera. What Lee and Auchus found out was that Provera could tame certain enzymes, (3HSDII) which influence hormone production, that low doses of Provera could disrupt GnRH production and high doses were needed for a therapeutic effect. By knowing all this, it brings about new ideas for drug therapy when dealing with certain diseases. Not scarcely that, but 3HSDII enzyme may be great to treat breast cancer. In this engage Lee and Au chus used yeast cells instead of human cells. This give ups them to study a single enzyme along with the effects that drugs may have on the production of steroids. Another advantage in using yeast cells is that these cells allow the maximum amount of an enzyme, cholesterol and protein needed, in order for the enzyme to perform. I study that Lee and Auchus expected these results based on their findings, but at the very(prenominal) time were surprised by some of their findings in regards to other diseases they leave behind be able to treat based on this research.